K25R (p.Lys25Arg) variant of CD2 (T-cell surface antigen CD2)
K25R (p.Lys25Arg) in CD2 (T-cell surface antigen CD2) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
K25R (p.Lys25Arg) variant details
- p.Lys25Arg
- rs1201404636
- ClinGen CA341839397
- ClinVar RCV004363726
- gnomAD rs1201404636
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.103
- REVEL 0.08
- MetaLR 0.09
- MetaSVM -1.00
- CADD 1.41
- PolyPhen-2 0.01
- SIFT 0.41
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available