E80K (p.Glu80Lys) variant of CD2 (T-cell surface antigen CD2)
E80K (p.Glu80Lys) in CD2 (T-cell surface antigen CD2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
E80K (p.Glu80Lys) variant details
- p.Glu80Lys
- NCI-TCGA Cosmic COSV6564
- cosmic curated COSV65643
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0942
- REVEL 0.07
- MetaLR 0.04
- MetaSVM -1.09
- CADD 0.00
- PolyPhen-2 0.01
- SIFT 0.96
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available