V25E (p.Val25Glu) variant of CCR5 (C-C chemokine receptor type 5)
V25E (p.Val25Glu) in CCR5 (C-C chemokine receptor type 5) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
V25E (p.Val25Glu) variant details
- p.Val25Glu
- rs751650495
- ClinGen CA2354555
- ClinVar RCV003410720
- ClinVar RCV004897803
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.358
- REVEL 0.21
- CADD 20.30
- PolyPhen-2 0.03
- SIFT 0.13
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Middle Eastern population (allele frequency 0.00087)
- Structural context available