I12T (p.Ile12Thr) variant of CCR5 (C-C chemokine receptor type 5)
I12T (p.Ile12Thr) in CCR5 (C-C chemokine receptor type 5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
I12T (p.Ile12Thr) variant details
- p.Ile12Thr
- ExAC rs781613165
- gnomAD rs781613165
- Missense
- Variant Prioritization Score for Impact Estimate 0.112
- REVEL 0.13
- CADD 4.08
- PolyPhen-2 0.25
- SIFT 0.18
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available