I12S (p.Ile12Ser) variant of CCR5 (C-C chemokine receptor type 5)
I12S (p.Ile12Ser) in CCR5 (C-C chemokine receptor type 5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
I12S (p.Ile12Ser) variant details
- p.Ile12Ser
- ExAC rs781613165
- gnomAD rs781613165
- Missense
- Variant Prioritization Score for Impact Estimate 0.122
- REVEL 0.13
- CADD 6.48
- PolyPhen-2 0.20
- SIFT 0.14
- Most common in the Latino/Admixed American population (allele frequency 6.8e-05)
- Structural context available