D66G (p.Asp66Gly) variant of CCR5 (C-C chemokine receptor type 5)
D66G (p.Asp66Gly) in CCR5 (C-C chemokine receptor type 5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
D66G (p.Asp66Gly) variant details
- p.Asp66Gly
- NCI-TCGA Cosmic COSV5275
- cosmic curated COSV52751
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.643
- REVEL 0.66
- CADD 25.00
- PolyPhen-2 0.99
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available