G20D (p.Gly20Asp) variant of CCNE1 (G1/S-specific cyclin-E1)
G20D (p.Gly20Asp) in CCNE1 (G1/S-specific cyclin-E1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
G20D (p.Gly20Asp) variant details
- p.Gly20Asp
- NCI-TCGA Cosmic COSV9938
- cosmic curated COSV99388
- Ensembl rs2145715116
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.26
- REVEL 0.06
- CADD 20.20
- PolyPhen-2 0.06
- SIFT 0.32
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available