R87C (p.Arg87Cys) variant of CCND3 (G1/S-specific cyclin-D3)
R87C (p.Arg87Cys) in CCND3 (G1/S-specific cyclin-D3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
R87C (p.Arg87Cys) variant details
- p.Arg87Cys
- rs889367305
- NCI-TCGA Cosmic COSV1008
- cosmic curated COSV10088
- TOPMed rs889367305
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.653
- REVEL 0.52
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available