E115K (p.Glu115Lys) variant of CCND3 (G1/S-specific cyclin-D3)
E115K (p.Glu115Lys) in CCND3 (G1/S-specific cyclin-D3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
E115K (p.Glu115Lys) variant details
- p.Glu115Lys
- rs756727994
- NCI-TCGA Cosmic COSV1008
- NCI-TCGA Cosmic COSV6591
- cosmic curated COSV65913
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.613
- REVEL 0.47
- CADD 29.90
- PolyPhen-2 0.75
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available