C91Y (p.Cys91Tyr) variant of CCND3 (G1/S-specific cyclin-D3)
C91Y (p.Cys91Tyr) in CCND3 (G1/S-specific cyclin-D3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
C91Y (p.Cys91Tyr) variant details
- p.Cys91Tyr
- 1000Genomes rs150497154
- ESP rs150497154
- ExAC rs150497154
- TOPMed rs150497154
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.262
- REVEL 0.06
- CADD 22.10
- PolyPhen-2 0.64
- SIFT 0.55
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the 1KG:MSL population (allele frequency 0.0063)
- Structural context available