T32A (p.Thr32Ala) variant of CCND2 (G1/S-specific cyclin-D2)
T32A (p.Thr32Ala) in CCND2 (G1/S-specific cyclin-D2) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as conflicting interpretations in the context of not provided; not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
T32A (p.Thr32Ala) variant details
- p.Thr32Ala
- rs772187536
- ClinGen CA6395152
- ClinVar RCV002576981
- ClinVar RCV005433841
- Conflicting interpretations
- not provided; not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.298
- REVEL 0.19
- MetaLR 0.01
- MetaSVM -0.88
- CADD 23.30
- PolyPhen-2 0.15
- SIFT 0.21
- ClinVar: Conflicting classifications of pathogenicity (not provided; not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available