R22G (p.Arg22Gly) variant of CCND2 (G1/S-specific cyclin-D2)
R22G (p.Arg22Gly) in CCND2 (G1/S-specific cyclin-D2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
R22G (p.Arg22Gly) variant details
- p.Arg22Gly
- ExAC rs778299007
- TOPMed rs778299007
- gnomAD rs778299007
- Missense
- Variant Prioritization Score for Impact Estimate 0.107
- REVEL 0.02
- MetaLR 0.02
- MetaSVM -0.97
- CADD 14.80
- PolyPhen-2 0.00
- SIFT 0.37
- Most common in the East Asian population (allele frequency 0.00058)
- Structural context available