L3P (p.Leu3Pro) variant of CCND2 (G1/S-specific cyclin-D2)
L3P (p.Leu3Pro) in CCND2 (G1/S-specific cyclin-D2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
L3P (p.Leu3Pro) variant details
- p.Leu3Pro
- gnomAD 12-4274048-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.47
- REVEL 0.40
- MetaLR 0.14
- MetaSVM -0.77
- CADD 30.00
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available