I33S (p.Ile33Ser) variant of CCND2 (G1/S-specific cyclin-D2)
I33S (p.Ile33Ser) in CCND2 (G1/S-specific cyclin-D2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
I33S (p.Ile33Ser) variant details
- p.Ile33Ser
- TOPMed rs1009356572
- Missense
- Variant Prioritization Score for Impact Estimate 0.336
- REVEL 0.20
- MetaLR 0.01
- MetaSVM -0.96
- CADD 23.40
- PolyPhen-2 0.07
- SIFT 0.11
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available