E35K (p.Glu35Lys) variant of CCND2 (G1/S-specific cyclin-D2)
E35K (p.Glu35Lys) in CCND2 (G1/S-specific cyclin-D2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
E35K (p.Glu35Lys) variant details
- p.Glu35Lys
- TOPMed rs1565430722
- gnomAD rs1565430722
- Missense
- Variant Prioritization Score for Impact Estimate 0.465
- REVEL 0.31
- MetaLR 0.05
- MetaSVM -1.06
- CADD 32.00
- PolyPhen-2 0.53
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available