P18S (p.Pro18Ser) variant of CCND1 (G1/S-specific cyclin-D1)
P18S (p.Pro18Ser) in CCND1 (G1/S-specific cyclin-D1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
P18S (p.Pro18Ser) variant details
- p.Pro18Ser
- rs772857967
- NCI-TCGA Cosmic COSV5712
- cosmic curated COSV57121
- ExAC rs772857967
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.352
- REVEL 0.09
- CADD 21.60
- PolyPhen-2 0.00
- SIFT 0.66
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available