P18L (p.Pro18Leu) variant of CCND1 (G1/S-specific cyclin-D1)
P18L (p.Pro18Leu) in CCND1 (G1/S-specific cyclin-D1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
P18L (p.Pro18Leu) variant details
- p.Pro18Leu
- NCI-TCGA Cosmic COSV5712
- Ensembl rs2120080068
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.07
- CADD 21.40
- PolyPhen-2 0.00
- SIFT 0.45
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available