L23F (p.Leu23Phe) variant of CCND1 (G1/S-specific cyclin-D1)
L23F (p.Leu23Phe) in CCND1 (G1/S-specific cyclin-D1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
L23F (p.Leu23Phe) variant details
- p.Leu23Phe
- ExAC rs753863475
- gnomAD rs753863475
- Missense
- Variant Prioritization Score for Impact Estimate 0.355
- REVEL 0.16
- CADD 23.80
- PolyPhen-2 0.02
- SIFT 0.03
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available