D25Y (p.Asp25Tyr) variant of CCND1 (G1/S-specific cyclin-D1)
D25Y (p.Asp25Tyr) in CCND1 (G1/S-specific cyclin-D1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, published literature, and structural context.
D25Y (p.Asp25Tyr) variant details
- p.Asp25Tyr
- gnomAD 11-69641386-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.489
- REVEL 0.41
- MetaLR 0.11
- MetaSVM -0.93
- CADD 32.00
- PolyPhen-2 0.87
- SIFT 0.00
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available
- Literature evidence available