C8W (p.Cys8Trp) variant of CCND1 (G1/S-specific cyclin-D1)
C8W (p.Cys8Trp) in CCND1 (G1/S-specific cyclin-D1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
C8W (p.Cys8Trp) variant details
- p.Cys8Trp
- TOPMed rs1855696875
- gnomAD rs1855696875
- Missense
- Variant Prioritization Score for Impact Estimate 0.379
- REVEL 0.25
- CADD 24.00
- PolyPhen-2 0.25
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 0.00026)
- Structural context available