G81D (p.Gly81Asp) variant of CASP9 (Caspase-9)
G81D (p.Gly81Asp) in CASP9 (Caspase-9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
G81D (p.Gly81Asp) variant details
- p.Gly81Asp
- rs1366684407
- NCI-TCGA Cosmic COSV6160
- cosmic curated COSV61601
- TOPMed rs1366684407
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.14
- CADD 20.20
- PolyPhen-2 0.43
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available