S4I (p.Ser4Ile) variant of CASP8 (Caspase-8)
S4I (p.Ser4Ile) in CASP8 (Caspase-8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data and structural context.
S4I (p.Ser4Ile) variant details
- p.Ser4Ile
- cosmic curated COSV10940
- TOPMed rs1456626812
- gnomAD rs1456626812
- Missense
- Variant Prioritization Score for Impact Estimate 0.0543
- CADD 0.19
- PolyPhen-2 0.05
- SIFT 0.16
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available