I10T (p.Ile10Thr) variant of CASP8 (Caspase-8)
I10T (p.Ile10Thr) in CASP8 (Caspase-8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
I10T (p.Ile10Thr) variant details
- p.Ile10Thr
- NCI-TCGA Cosmic COSV5185
- cosmic curated COSV51852
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.627
- CADD 24.10
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available