I10M (p.Ile10Met) variant of CASP8 (Caspase-8)
I10M (p.Ile10Met) in CASP8 (Caspase-8) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, published literature, and structural context.
I10M (p.Ile10Met) variant details
- p.Ile10Met
- gnomAD 2-201258262-AT-A
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.14
- CADD 8.32
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available
- Literature evidence available