F3C (p.Phe3Cys) variant of CASP8 (Caspase-8)
F3C (p.Phe3Cys) in CASP8 (Caspase-8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
F3C (p.Phe3Cys) variant details
- p.Phe3Cys
- cosmic curated COSV51847
- gnomAD rs1264556426
- Missense
- Variant Prioritization Score for Impact Estimate 0.471
- CADD 23.90
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available