R64L (p.Arg64Leu) variant of CASP3 (Caspase-3)
R64L (p.Arg64Leu) in CASP3 (Caspase-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data, published literature, and structural context.
R64L (p.Arg64Leu) variant details
- p.Arg64Leu
- gnomAD 4-184632384-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.54
- REVEL 0.41
- CADD 29.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- Literature evidence available