R111S (p.Arg111Ser) variant of CASP3 (Caspase-3)
R111S (p.Arg111Ser) in CASP3 (Caspase-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R111S (p.Arg111Ser) variant details
- p.Arg111Ser
- TOPMed rs1742056787
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.18
- CADD 20.40
- PolyPhen-2 0.07
- SIFT 0.91
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available