L91F (p.Leu91Phe) variant of CASP3 (Caspase-3)
L91F (p.Leu91Phe) in CASP3 (Caspase-3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
L91F (p.Leu91Phe) variant details
- p.Leu91Phe
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10039
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.433
- REVEL 0.21
- CADD 21.80
- PolyPhen-2 0.37
- SIFT 0.28
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available