K105E (p.Lys105Glu) variant of CASP3 (Caspase-3)
K105E (p.Lys105Glu) in CASP3 (Caspase-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
K105E (p.Lys105Glu) variant details
- p.Lys105Glu
- gnomAD rs1280426773
- Missense
- Variant Prioritization Score for Impact Estimate 0.135
- REVEL 0.05
- CADD 15.60
- PolyPhen-2 0.01
- SIFT 0.72
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available