H22R (p.His22Arg) variant of CASP3 (Caspase-3)
H22R (p.His22Arg) in CASP3 (Caspase-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
H22R (p.His22Arg) variant details
- p.His22Arg
- rs35578277
- UniProt VAR 048616
- 1000Genomes rs35578277
- ESP rs35578277
- Missense
- Variant Prioritization Score for Impact Estimate 0.224
- REVEL 0.09
- CADD 17.60
- PolyPhen-2 0.16
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available