H121R (p.His121Arg) variant of CASP3 (Caspase-3)
H121R (p.His121Arg) in CASP3 (Caspase-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
H121R (p.His121Arg) variant details
- p.His121Arg
- TOPMed rs1742053469
- Missense
- Variant Prioritization Score for Impact Estimate 0.695
- REVEL 0.74
- CADD 25.90
- PolyPhen-2 0.77
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available