F91L (p.Phe91Leu) variant of CARD11 (Q9BXL7)
F91L (p.Phe91Leu) in CARD11 (Q9BXL7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
F91L (p.Phe91Leu) variant details
- p.Phe91Leu
- rs1407244585
- NCI-TCGA Cosmic COSV6271
- gnomAD rs1407244585
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.32
- CADD 27.40
- PolyPhen-2 0.95
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available