T6I (p.Thr6Ile) variant of CALCRL (Q16602)
T6I (p.Thr6Ile) in CALCRL (Q16602) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
T6I (p.Thr6Ile) variant details
- p.Thr6Ile
- rs780410767
- NCI-TCGA Cosmic COSV6647
- cosmic curated COSV66477
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.208
- REVEL 0.02
- CADD 0.28
- PolyPhen-2 0.00
- SIFT 0.70
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available