Y26C (p.Tyr26Cys) variant of C3 (Complement C3)
Y26C (p.Tyr26Cys) in C3 (Complement C3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
Y26C (p.Tyr26Cys) variant details
- p.Tyr26Cys
- gnomAD rs963344483
- Missense
- Variant Prioritization Score for Impact Estimate 0.258
- REVEL 0.25
- AlphaMissense 0.13
- MetaLR 0.09
- MetaSVM -1.02
- CADD 21.70
- PolyPhen-2 0.96
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available