V159L (p.Val159Leu) variant of C3 (Complement C3)
V159L (p.Val159Leu) in C3 (Complement C3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
V159L (p.Val159Leu) variant details
- p.Val159Leu
- gnomAD rs1255051177
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.09
- CADD 13.50
- PolyPhen-2 0.08
- SIFT 0.35
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available