P18T (p.Pro18Thr) variant of C3 (Complement C3)
P18T (p.Pro18Thr) in C3 (Complement C3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
P18T (p.Pro18Thr) variant details
- p.Pro18Thr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.306
- REVEL 0.27
- CADD 18.60
- PolyPhen-2 0.13
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available