M25T (p.Met25Thr) variant of C3 (Complement C3)
M25T (p.Met25Thr) in C3 (Complement C3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
M25T (p.Met25Thr) variant details
- p.Met25Thr
- gnomAD rs1334683171
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.35
- CADD 22.80
- PolyPhen-2 0.20
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.1e-06)
- Structural context available