P15L (p.Pro15Leu) variant of BRD4 (Bromodomain-containing protein 4)
P15L (p.Pro15Leu) in BRD4 (Bromodomain-containing protein 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P15L (p.Pro15Leu) variant details
- p.Pro15Leu
- rs369254108
- cosmic curated COSV54586
- ESP rs369254108
- TOPMed rs369254108
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.588
- MetaLR 0.11
- MetaSVM -1.01
- CADD 27.20
- PolyPhen-2 0.66
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- BRD4 NET domain domainome 1.0: score -0.0498