L21Q (p.Leu21Gln) variant of BRD4 (Bromodomain-containing protein 4)
L21Q (p.Leu21Gln) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L21Q (p.Leu21Gln) variant details
- p.Leu21Gln
- ExAC rs762451591
- TOPMed rs762451591
- gnomAD rs762451591
- Missense
- Variant Prioritization Score for Impact Estimate 0.51
- MetaLR 0.14
- MetaSVM -0.91
- CADD 27.60
- PolyPhen-2 0.89
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- BRD4 NET domain domainome 1.0: score 0.0444