L21P (p.Leu21Pro) variant of BRD4 (Bromodomain-containing protein 4)
L21P (p.Leu21Pro) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L21P (p.Leu21Pro) variant details
- p.Leu21Pro
- ExAC rs762451591
- TOPMed rs762451591
- gnomAD rs762451591
- Missense
- Variant Prioritization Score for Impact Estimate 0.513
- MetaLR 0.14
- MetaSVM -0.91
- CADD 28.30
- PolyPhen-2 0.85
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- BRD4 NET domain domainome 1.0: score 0.0444