L14V (p.Leu14Val) variant of BRD4 (Bromodomain-containing protein 4)
L14V (p.Leu14Val) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L14V (p.Leu14Val) variant details
- p.Leu14Val
- Ensembl rs2145625511
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- MetaLR 0.04
- MetaSVM -1.07
- CADD 20.20
- PolyPhen-2 0.06
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- BRD4 NET domain domainome 1.0: score -0.224