G6S (p.Gly6Ser) variant of BRD4 (Bromodomain-containing protein 4)
G6S (p.Gly6Ser) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G6S (p.Gly6Ser) variant details
- p.Gly6Ser
- TOPMed rs200468125
- gnomAD rs200468125
- Missense
- Variant Prioritization Score for Impact Estimate 0.543
- MetaLR 0.07
- MetaSVM -1.09
- CADD 21.80
- PolyPhen-2 0.01
- SIFT 0.02
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- BRD4 NET domain domainome 1.0: score -0.253