G20E (p.Gly20Glu) variant of BRD4 (Bromodomain-containing protein 4)
G20E (p.Gly20Glu) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G20E (p.Gly20Glu) variant details
- p.Gly20Glu
- gnomAD rs1290547844
- Missense
- Variant Prioritization Score for Impact Estimate 0.602
- MetaLR 0.21
- MetaSVM -0.74
- CADD 25.50
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available
- BRD4 NET domain domainome 1.0: score -0.256