A41G (p.Ala41Gly) variant of BRD4 (Bromodomain-containing protein 4)
A41G (p.Ala41Gly) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A41G (p.Ala41Gly) variant details
- p.Ala41Gly
- TOPMed rs1042996398
- gnomAD rs1042996398
- Missense
- Variant Prioritization Score for Impact Estimate 0.542
- MetaLR 0.05
- MetaSVM -1.03
- CADD 22.00
- PolyPhen-2 0.04
- SIFT 0.22
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available
- BRD4 NET domain domainome 1.0: score 0.104