A33S (p.Ala33Ser) variant of BRD4 (Bromodomain-containing protein 4)
A33S (p.Ala33Ser) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A33S (p.Ala33Ser) variant details
- p.Ala33Ser
- ExAC rs748256356
- gnomAD rs748256356
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- MetaLR 0.05
- MetaSVM -1.07
- CADD 18.30
- PolyPhen-2 0.12
- SIFT 0.26
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- BRD4 NET domain domainome 1.0: score -0.18