A31S (p.Ala31Ser) variant of BRD4 (Bromodomain-containing protein 4)
A31S (p.Ala31Ser) in BRD4 (Bromodomain-containing protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A31S (p.Ala31Ser) variant details
- p.Ala31Ser
- TOPMed rs1408837255
- gnomAD rs1408837255
- Missense
- Variant Prioritization Score for Impact Estimate 0.566
- MetaLR 0.12
- MetaSVM -0.97
- CADD 21.50
- PolyPhen-2 0.60
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- BRD4 NET domain domainome 1.0: score -0.789