L39F (p.Leu39Phe) variant of BRD2 (Bromodomain-containing protein 2)
L39F (p.Leu39Phe) in BRD2 (Bromodomain-containing protein 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
L39F (p.Leu39Phe) variant details
- p.Leu39Phe
- gnomAD rs1287500847
- Missense
- Variant Prioritization Score for Impact Estimate 0.324
- REVEL 0.19
- CADD 24.30
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available