T10P (p.Thr10Pro) variant of BRCA2 (P51587)
T10P (p.Thr10Pro) in BRCA2 (P51587) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The record also includes variant effect predictions and published literature.
T10P (p.Thr10Pro) variant details
- p.Thr10Pro
- rs786203080
- ClinGen CA387752984
- ClinVar RCV000794446
- Ensembl rs786203080
- Likely benign
- Missense
- AlphaMissense 0.20
- MetaLR 0.01
- MetaSVM -0.98
- SIFT 0.00
- MutPred 0.32
- EBI: Likely benign
- UniProt: Likely benign
- Cited in: American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility. (PMID 12692171)
- Cited in: Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors. (PMID 15604628)