T57S (p.Thr57Ser) variant of BRAF (P15056)
T57S (p.Thr57Ser) in BRAF (P15056) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T57S (p.Thr57Ser) variant details
- p.Thr57Ser
- gnomAD rs1354935301
- Missense
- Variant Prioritization Score for Impact Estimate 0.531
- MetaLR 0.40
- MetaSVM -0.35
- CADD 23.30
- PolyPhen-2 0.12
- SIFT 0.04
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.0909