R426T (p.Arg426Thr) variant of BRAF (P15056)
R426T (p.Arg426Thr) in BRAF (P15056) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic in the context of Lip and oral cavity carcinoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes structural context.
R426T (p.Arg426Thr) variant details
- p.Arg426Thr
- rs1801030116
- ClinGen CA369589365
- ClinVar RCV001255637
- Ensembl rs1801030116
- Pathogenic
- Lip and oral cavity carcinoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- AlphaMissense 0.23
- MetaLR 0.33
- MetaSVM -0.65
- PolyPhen-2 0.11
- EVE 0.18
- MutPred 0.30
- ClinVar: Pathogenic (Lip and oral cavity carcinoma)
- EBI: Pathogenic
- UniProt: Pathogenic
- Structural context available